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. 2016 Nov 12;8(1):191–202. doi: 10.18632/oncotarget.13329

Figure 2. Comparative analysis of DNA methylation and gene expression between IDH-wildtype and IDH-mutant gliomas.

Figure 2

A. Heat maps of mean DNA methylation values (left) and mean mRNA levels (right) of corresponding genes are presented with statistical significance marked between IDH and IDHm groups. B.-D. Protein abundance (in z-scores) of specified genes are presented in box-and-whisker plots. E. Phosphorylation of ERBB3 (p-ERBB3) at Y1289 and AKT (p-AKT) at S473 and T308 are presented in the same way as above. Unpaired t-tests were performed for comparison between IDH and IDHm groups. *, p < 0.05; ***, p < 0.001.