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. 2016 Nov 12;8(1):191–202. doi: 10.18632/oncotarget.13329

Figure 3. Evaluation of differentially expressed genes in the RTK-PI3K-AKT pathway with respect to glioma patient survival.

Figure 3

A. and C. Overall survival with respect to mRNA levels of RTK genes A. and PI3K-AKT genes C. that were differentially expressed between IDH and IDHm groups. B. Overall survival with respect to ERBB3 abundance and ERBB3 and AKT phosphorylation. Decreased (< 0 in z-scores) and increased (> 0 in z-scores) protein abundance and phosphorylation were used for log-rank (Mantel-Cox) tests and presented with p values (unless not significant). The survival curves with statistical significance were compared with those of IDH-wildtype and IDH-mutant gliomas.