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. 2016 Nov 12;8(1):191–202. doi: 10.18632/oncotarget.13329

Figure 6. IGFBP2 is prognostic across all histological types of glioma.

Figure 6

A. A heat map depicts distinctive patterns of gene expression between IDH-wildtype and IDH-mutant gliomas (All) but a shared pattern among oligodendroglioma (ODG), oligoastrocytoma (OAC), and astrocytoma (AC) of the same IDH status. The listed genes were all associated with glioma patient survival. B. and C. IGFBP2 mRNA levels were compared between IDH and IDHm groups in each histological type B. and between tumor grades C.. D. Differential IGFBP2 expression correlated with distinct patterns of survival in all histological types in reference to their respective survival curves (in dotted lines). E. Within IDH-mutant gliomas, there was no statistical difference in mean IGFBP2 expression between subtypes with and without 1p/19q deletions, and between gliomas with and without mutations in CIC, FUBP1, and/or NOTCH1 and between those with and without mutations in TP53 and/or ATRX.