Table 3. Meta-analysis results.
| Comparisons | OR | 95%CI | P(OR) I2 | Heterogeneity | Effects model | P(Begg) | P(Egger) | |
|---|---|---|---|---|---|---|---|---|
| P | ||||||||
| Allele contrast genetic model | ||||||||
| rs3746444 | 1.17 | 1.04–1.31 | 0.008 | 58% | 0.014 | R | 0.602 | 0.796 |
| Asian | 1.24 | 1.08–1.42 | 0.002 | 48% | 0.071 | R | - | - |
| Caucasian | 1.03 | 0.92–1.15 | 0.628 | 0% | 0.924 | F | - | - |
| rs11614913 | 0.98 | 0.89–1.09 | 0.748 | 73% | 0.000 | R | 0.753 | 0.718 |
| Asian | 0.99 | 0.85–1.17 | 0.932 | 76% | 0.000 | R | - | - |
| Caucasian | 0.93 | 0.87–1.00 | 0.044 | 37% | 0.173 | F | - | - |
| rs2910164 | 0.97 | 0.87–1.07 | 0.510 | 64% | 0.001 | R | 0.161 | 0.292 |
| Asian | 1.02 | 0.94–1.10 | 0.702 | 16% | 0.303 | F | - | - |
| Caucasian | 0.92 | 0.74–1.14 | 0.453 | 84% | 0.000 | R | - | - |
| Homozygote genetic model | ||||||||
| rs3746444 | 1.41 | 1.19–1.67 | 0.000 | 34% | 0.147 | F | 1.000 | 0.768 |
| Asian | 1.64 | 1.34–2.02 | 0.000 | 0% | 0.543 | F | - | - |
| Caucasian | 1.03 | 0.77–1.38 | 0.844 | 0% | 0.381 | F | - | - |
| rs11614913 | 0.95 | 0.77–1.16 | 0.600 | 71% | 0.000 | R | 0.488 | 0.538 |
| Asian | 0.98 | 0.71–1.34 | 0.877 | 73% | 0.000 | R | - | - |
| Caucasian | 0.85 | 0.73–0.99 | 0.037 | 52% | 0.080 | R | - | - |
| rs2910164 | 1.03 | 0.80–1.33 | 0.804 | 64% | 0.001 | R | 0.246 | 0.554 |
| Asian | 1.11 | 0.94–1.32 | 0.221 | 0% | 0.474 | F | - | - |
| Caucasian | 0.95 | 0.52–1.72 | 0.862 | 85% | 0.000 | R | - | - |
| Heterozygote genetic model | ||||||||
| rs3746444 | 1.10 | 1.01–1.21 | 0.036 | 26% | 0.209 | F | 1.000 | 0.610 |
| Asian | 1.15 | 1.02–1.30 | 0.022 | 32% | 0.186 | F | - | - |
| Caucasian | 1.04 | 0.91–1.20 | 0.572 | 0% | 0.334 | F | - | - |
| rs11614913 | 1.03 | 0.92–1.15 | 0.577 | 47% | 0.019 | R | 0.964 | 0.671 |
| Asian | 1.07 | 0.89–1.28 | 0.481 | 57% | 0.014 | R | - | - |
| Caucasian | 0.95 | 0.86–1.06 | 0.348 | 0% | 0.887 | F | - | - |
| rs2910164 | 0.95 | 0.83–1.08 | 0.403 | 54% | 0.011 | R | 0.951 | 0.598 |
| Asian | 0.98 | 0.80–1.20 | 0.866 | 58% | 0.019 | R | - | - |
| Caucasian | 0.91 | 0.77–1.07 | 0.241 | 51% | 0.085 | R | - | - |
| Dominant genetic model | ||||||||
| rs3746444 | 1.16 | 1.06–1.26 | 0.001 | 19% | 0.272 | F | 0.466 | 0.332 |
| Asian | 1.25 | 1.12–1.40 | 0.000 | 0% | 0.509 | F | - | - |
| Caucasian | 1.04 | 0.91–1.89 | 0.569 | 0% | 0.536 | F | - | - |
| rs11614913 | 1.01 | 0.89–1.15 | 0.837 | 66% | 0.000 | R | 0.893 | 0.885 |
| Asian | 1.08 | 0.89–1.32 | 0.442 | 72% | 0.000 | R | - | - |
| Caucasian | 0.93 | 0.84–1.02 | 0.136 | 0% | 0.533 | F | - | - |
| rs2910164 | 0.95 | 0.83–1.08 | 0.453 | 59% | 0.003 | R | 0.855 | 0.478 |
| Asian | 1.00 | 0.83–1.19 | 0.960 | 50% | 0.053 | R | - | - |
| Caucasian | 0.90 | 0.73–1.11 | 0.317 | 73% | 0.005 | R | - | - |
| Recessive genetic model | ||||||||
| rs3746444 | 1.29 | 0.97–1.71 | 0.083 | 66% | 0.003 | R | 0.754 | 0.883 |
| Asian | 1.38 | 0.97–1.96 | 0.070 | 67% | 0.006 | R | - | - |
| Caucasian | 1.01 | 0.75–1.34 | 0.971 | 11% | 0.289 | F | - | - |
| rs11614913 | 0.93 | 0.80–1.08 | 0.324 | 58% | 0.002 | R | 0.138 | 0.286 |
| Asian | 0.98 | 0.79–1.21 | 0.843 | 62% | 0.005 | R | - | - |
| Caucasian | 0.88 | 0.76–1.01 | 0.062 | 45% | 0.120 | F | - | - |
| rs2910164 | 1.03 | 0.82–1.29 | 0.784 | 62% | 0.001 | R | 0.669 | 0.879 |
| Asian | 1.03 | 0.89–1.19 | 0.686 | 14% | 0.319 | F | - | - |
| Caucasian | 1.00 | 0.57–1.73 | 0.986 | 83% | 0.000 | R | - | - |
F: fixed effects model; R: random effects model.