Table 1. Fosaprepitant treatment leads to significant and specific gene expression changes in TP53, EGFR and chemotherapy induced gene sets.
| Gene Set | Rank | Size | NES | FDR q-val |
|---|---|---|---|---|
| Upregulated | ||||
| ZHANG TLX TARGETS DN | 1 | 66 | 2.56 | 0.00 |
| PODAR RESPONSE TO ADAPHOSTIN UP | 2 | 116 | 2.53 | 0.00 |
| KERLEY RESPONSE TO CISPLATIN UP | 3 | 29 | 2.50 | 0.00 |
| SMIRNOV RESPONSE TO IR 6HR UP | 4 | 133 | 2.45 | 0.00 |
| KRIGE AMMINO ACID DEPRIVATION | 5 | 25 | 2.41 | 0.00 |
| KANNAN TP53 TARGETS UP | 6 | 47 | 2.39 | 0.00 |
| WARTERS RESPONSE TO IR SKIN | 7 | 56 | 2.36 | 0.00 |
| ZHANG TLX TARGETS 60HR UP | 8 | 200 | 2.36 | 0.00 |
| KOBAYASHI EGFR SIGNALING 24HR UP | 9 | 69 | 2.33 | 0.00 |
| CHANG CORE SERUM RESPONSE DN | 10 | 148 | 2.29 | 0.00 |
| WARTERS IR RESPONSE 5GY | 11 | 31 | 2.29 | 0.00 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 UP | 12 | 52 | 2.27 | 0.00 |
| TIEN INTESTINE PROBIOTICS 24HR DN | 13 | 189 | 2.26 | 0.00 |
| ODONNELL TFRC TARGETS UP | 14 | 225 | 2.25 | 0.00 |
| GHANDHI DIRECT IRRADIATION UP | 15 | 54 | 2.25 | 0.00 |
| ZHANG TLX TARGETS 36HR UP | 16 | 155 | 2.23 | 0.00 |
| VARELA ZMPSTE24 TARGETS UP | 17 | 29 | 2.23 | 0.00 |
| RUIZ TNC TARGETS UP | 18 | 106 | 2.21 | 0.00 |
| ONDER CDH1 TARGETS 1 UP | 19 | 92 | 2.21 | 0.00 |
| PRAMOONJAGO SOX4 TARGETS UP | 20 | 43 | 2.21 | 0.00 |
| Downregulated | ||||
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 1 | 283 | −3.44 | 0.00 |
| ROSTY CERVICAL CANCER PROLIFERATION CLUSTER | 2 | 136 | −3.21 | 0.00 |
| KOBAYASHI EGFR SIGNALING 24HR DN | 3 | 223 | −3.20 | 0.00 |
| ZHANG TLX TARGETS 60HR DN | 4 | 254 | −3.17 | 0.00 |
| FUJII YBX1 TARGETS DN | 5 | 188 | −3.12 | 0.00 |
| ZHOU CELL CYCLE GENES IN IR RESPONSE 6HR | 6 | 79 | −3.08 | 0.00 |
| SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP | 7 | 144 | −3.06 | 0.00 |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 8 | 149 | −3.03 | 0.00 |
| MANALO HYPOXIA DN | 9 | 272 | −3.02 | 0.00 |
| CROONQUIST IL6 DEPRIVATION DN | 10 | 93 | −3.00 | 0.00 |
| ZHANG TLX TARGETS UP | 11 | 84 | −2.99 | 0.00 |
| KONG E2F3 TARGETS | 12 | 86 | −2.99 | 0.00 |
| BURTON ADIPOGENESIS 3 | 13 | 91 | −2.98 | 0.00 |
| BLUM RESPONSE TO SALIRASIB DN | 14 | 320 | −2.98 | 0.00 |
| MOLENAAR TARGETS OF CCND1 AND CDK4 DN | 15 | 54 | −2.96 | 0.00 |
| GRAHAM NORMAL QUIESCENT VS NORMAL DEVIDING DN | 16 | 77 | −2.95 | 0.00 |
| ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR | 17 | 112 | −2.93 | 0.00 |
| CROONQUIST NRAS SIGNALLING DN | 18 | 72 | −2.91 | 0.00 |
| ZHANG TLX TARGETS 36HR DN | 19 | 176 | −2.91 | 0.00 |
| SHEDDEN LUNG CANCER POOR SURVIVAL A6 | 20 | 408 | −2.90 | 0.00 |
Table of top 20 up- and down-regulated gene sets from the MSigDB C2 collection, enriched among genes induced by inhibition of the TACR1 based on GSEA (rank, rank of gene set in overall list of gene sets, ranked according to decreasing NES; size, number of genes in each set; NES, normalized enrichment score).