Table 2. Fosaprepitant leads to gene expression changes at a unique subset of transcription factor targets.
| Transcription factor | NES | #targets | #motifs |
|---|---|---|---|
| Upregulated genes | |||
| TP53 | 5.65 | 86 | 6 |
| FOXO4 | 5.20 | 117 | 35 |
| NFYA | 5.02 | 92 | 12 |
| JDP2 | 4.40 | 80 | 8 |
| MEIS1 | 3.74 | 52 | 4 |
| HOXA13 | 3.63 | 44 | 3 |
| Downregulated genes | |||
| E2F2 | 9.78 | 112 | 31 |
| BRF1 | 3.70 | 32 | 2 |
| TBP | 3.54 | 40 | 5 |
| KLF7 | 3.26 | 6 | 1 |
Table of transcription factors that bind to the motifs enriched among the genes up- and down-regulated upon administration of a low dose of the TACR1 antagonist to the IMR-5 cells (NES, normalized enrichment score, # targets, the number of merged targets found by numerous motifs, # motifs).