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. 2016 Nov 21;8(1):552–564. doi: 10.18632/oncotarget.13477

Figure 1. Endothelial Bcl-6/BCoR mRNA expression in response to tumor-derived stimuli.

Figure 1

(A) Bcl-6/BCoR mRNA levels were determined in ECs exposed to conditioned medium from three different colorectal cancer cell lines by real-time PCR using pan-reactive primer sets and are given in relation to untreated control. (B) The ratio of Bcl-6 V1/V2 splice variants and of BCoR transcripts with/without exon 5 or exon 8a was investigated in ECs treated with HT-29 supernatant for 1–4 hours. Specific primer sets were used to distinguish splice variants and the increase in mRNA levels was determined in relation to untreated control. The relative proportion of splice variants within the total amount of transcripts is illustrated by the colors grey and white. The results represent mean values and standard deviations of 2–3 independent experiments.