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. 2016 Nov 24;8(1):742–756. doi: 10.18632/oncotarget.13557

Figure 4. Treatment with TAK-659 effectively abrogates the co-culture-induced proliferation and activation of primary CLL cells.

Figure 4

Primary CLL cells from 10 patients pre-treated with increasing doses of TAK-659 were cultured with BMSC, CD40L, CpG ODN and anti-IgM for 48 hours and the expression of Ki-67 (A), CD86 (B), CD69 (C) and CD38 (D) was analyzed by FC. (E) Histograms from a representative patient. (*P < 0.05, **P < 0.01, ***P < 0.001, two-way ANOVA, Bonferroni's post-test. Graph shows mean ± SEM).