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. 2016 Nov 10;8(1):863–882. doi: 10.18632/oncotarget.13273

Figure 1. TRIM28 gene is overexpressed in breast cancer.

Figure 1

A. Box plot presents the TRIM28 gene expression level in primary breast tumor and normal tissue from TCGA project. The black line presents median, box shows interquantile region and whiskers - the highest (max) and the lowest (min) value. Outliers are also depicted. B. Differential expression analysis of TCGA BRCA patient samples for which tumor and matched normal tissues are available. Fold changes +/− 1.5 fold change are depicted. The black line presents median, box shows interquantile region and whiskers - the highest (max) and the lowest (min) value. Outliers are also depicted. C. TRIM28 gene expression is distinct between different BRCA PAM50 intrinsic subtypes. D. IHC for total TRIM28 and phosphorylated TRIM28 protein (TRIM28-S824) in selected breast cancer samples confirmed higher levels of TRIM28/phospho-TRIM28 in more aggressive breast cancer subtypes (basal and HER2+). Scale = 100 μm.