Figure 7. Knockdown of PSMC2 in SaoS-2 cells inhibited tumorigenicity in nude mice.
An equal number of cells (normal control and PSMC2 knockdown osteosarcoma cells) were inoculated subcutaneously into nude mice for up to 35 days. a. After scarification, xenograft tumors in vivo and excised tumors were recorded. b. Tumor volume was estimated based on the following equation: volume = 1/2 × (largest diameter) × (smallest diameter)2 and data were obtained from eight animals in each group presented as mean value ± SD. c. Bar graph presented the excised tumor weights derived from control or PSMC2 silenced SaoS-2 cells. **P < 0.01 as compared with normal control cells.