Table 2. Characteristics associated with overall survival.

Variable	Univariate Cox HR	P Value	Multivariate Cox HR	P Value
Age, per year	1.03	0.03	1.01	0.428
Male gender	0.67	0.13
Family history	2.26	0.06	3.73	0.02
Positive lymph nodes	2.61	0.019	3.68	0.013
Positive surgical margin	2.3	0.003	3.37	0.002
High-grade tumor	1.67	0.07	1.62	0.179
Chemotherapy	0.39	0.001	0.30	0.001
Radiotherapy	0.36	0.003	0.38	0.017
High TGFβ1 expression	0.35	0.009	0.29	0.017
High MKI67 expression	1.85	0.028	1.37	0.373
High COL1A2 expression	0.45	0.02	0.77	0.567