FIG.2.

Phylogenetic tree of Cape Town M. tuberculosis isolates with ≤6 IS6110 insertions. Genetic data from five different genotyping methods were subjected to phylogenetic analysis using the bootstrapping and neighbor-joining algorithms (see Materials and Methods). The tree was rooted to the principal genetic group 1 clone [isolate SA CT(67)]. Booststrap values are given at internal nodes. IS6110 insertions in defined genes, as well as DVR deletions, are indicated at the nodes where they occurred. All branches with zero length were collapsed. Isolate names are the same as in Table 3. Principal genetic groups 1 and 2 were assigned according to polymorphisms in the katG and gyrA genes (31). The scale indicates the number of steps per unit length.