Table 2.

Adverse events that warrant permanent discontinuation of atezolizumab treatment

Adverse events	Grade (CTCAE)
Pneumonitis	Grade 3 or 4
Infusion-related reactions	Grade 3 or 4
Ocular inflammatory toxicity	Grade 3 or 4
Pancreatitis	Grade 4 or any grade if recurrent
Diarrhea or colitis	Grade 4
Hypophysitis*	Grade 4
Rash	Grade 4
Meningoencephalitis	Any grade
Myasthenic syndrome/myasthenia gravis/Guillain–Barré	Any grade
AST or ALT >5× ULN	Grade 3 or 4
Total bilirubin >3× ULN	Grade 3 or 4

Note:

^*Due to probably permanent damage of the gland, experts consider continuation of atezolizumab with hormonal substitution a possible approach.

Abbreviations: CTCAE, Common Terminology Criteria for Adverse Events; ULN, upper limit of normal; AST, aspartate aminotransferase; ALT, alanine aminotransferase.