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Independent and dependent variables of ketoconazole PLGA NPs used in the central composite experimental design
| Independent variables | Level
|
||
|---|---|---|---|
| Low | Medium | High | |
| X1 (%) | 3.0 | 4.5 | 6.0 |
| X2 (%) | 4.0 | 5 | 6.0 |
| X3 (%) | 1.0 | 2 | 3.0 |
|
| |||
| Dependent variables | Goal | ||
|
| |||
| Y1 (nm) | Minimize | ||
| Y2 (%) | Maximize | ||
Abbreviations: X1, PLGA in organic phase; X2, organic to aqueous phase; X3, PVA in aqueous phase; Y1, particle size; Y2, entrapment efficiency; PLGA, poly(lactide-co-glycolide); PVA, poly (vinyl alcohol).
