Table 2.
Experimental runs along with the observed and fitted values for the studied responses
| Run | X1 (%) | X2 (%) | X3 (%) | Y1 (nm)
|
Y2 (%)
|
||
|---|---|---|---|---|---|---|---|
| Observed (mean ± SD) |
Fitted | Observed (mean ± SD) |
Fitted | ||||
| 1 | 3.0 | 6.0 | 3.0 | 457.0±0.014 | 441.092 | 61.627±8.66 | 61.0401 |
| 2 | 4.5 | 5.0 | 3.682 | 729.0±0.040 | 711.058 | 70.023±6.96 | 67.7879 |
| 3 | 3.0 | 4.0 | 3.0 | 417.0±0.011 | 463.84 | 64.277±0.47 | 66.7802 |
| 4 | 6.0 | 6.0 | 3.0 | 995.0±0.024 | 1,090.13 | 67.354±1.11 | 68.227 |
| 5 | 4.5 | 3.318 | 2.0 | 483.0±0.019 | 526.614 | 83.453±3.08 | 78.0304 |
| 6 | 1.977 | 5.0 | 2.0 | 328.0±0.018 | 302.979 | 55.624±0.44 | 54.9099 |
| 7 | 6.0 | 4.0 | 1.0 | 477.0±0.012 | 520.366 | 69.122±1.19 | 72.6754 |
| 8 | 3.0 | 4.0 | 1.0 | 446.0±0.017 | 378.33 | 64.362±0.54 | 66.4575 |
| 9 | 7.023 | 5.0 | 2.0 | 982.0±0.083 | 968.19 | 69.666±0.78 | 66.182 |
| 10 | 4.5 | 6.682 | 2.0 | 945.0±0.043 | 862.554 | 67.524±3.06 | 68.7485 |
| 11 | 4.5 | 5.0 | 0.318 | 536.0±0.055 | 515.111 | 68.765±4.28 | 66.802 |
| 12 | 6.0 | 6.0 | 1.0 | 962.0±0.066 | 942.618 | 66.912±0.51 | 67.3773 |
| 13 | 3.0 | 6.0 | 1.0 | 356.0±0.017 | 457.081 | 60.911±0.99 | 60.505 |
| 14 | 6.0 | 4.0 | 3.0 | 843.0±0.047 | 769.377 | 69.938±1.19 | 73.3126 |
| 15 | 4.5 | 5.0 | 2.0 | 885.0±0.183 | 893.331 | 67.847±3.10 | 67.5697 |
| 16 | 4.5 | 5.0 | 2.0 | 895.0±0.174 | 893.331 | 66.572±0.96 | 67.5697 |
Abbreviations: X1, PLGA in organic phase; X2, organic to aqueous phase; X3, PVA in aqueous phase; Y1, particle size; Y2, entrapment efficiency; PLGA, poly(lactide-co-glycolide); SD, standard deviation; PVA, poly (vinyl alcohol).