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Redox-triggered release of (A) DOX and (B) TPL from DOX/TPL-1/0.2-loaded LPNPs in PBS (0.01 M, pH 7.4) with or without 10 mM DTT.
Note: P-values were calculated by the Student’s t-test: **P<0.005.
Abbreviations: DOX, doxorubicin; DTT, dithiothreitol; LPNPs, lipid–polymer hybrid nanoparticles; PBS, phosphate-buffered saline; TPL, triptolide.
