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. 2016 Dec 12;8(5):7265–7275. doi: 10.18632/oncotarget.13919

Figure 1. Hyperactive mTOR signaling in human endometrial hyperplasia and cancer.

Figure 1

Increased expression of pS6, a marker for mTOR activation, was observed in hyperplastic post-menopausal human endometrium compared to normal post-menopausal endometrium A.-D. Panel B and D is a higher magnification image of boxed area in panel A and C, respectively. H-score quantification of pS6 staining performed using Halo™ image analysis software E. TCGA dataset analysis for endometrial cancer showed alterations in components of the PI3K-mTOR pathway F. *P < 0.05, Student's t-test.