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. 2016 Jun 6;8(5):7489–7501. doi: 10.18632/oncotarget.9841

Figure 1. HDAC8 showed a tumor-specific expression pattern and strong correlation with the clinical outcome of HCC patients.

Figure 1

A. Heat map analysis of cDNA microarray data of “high“ AHR HCC tumors compared with data from adjacent samples of healthy liver tissue. High HDAC8 mRNA expression was detected in HCC tumors with high AHR expression. B. HDAC8 mRNA was overexpressed in HCC tumor samples compared with non-HCC liver samples. C. HDAC8 expression showed a tumor-specific pattern in HCC tumor samples. HDAC8, brown; HDAC8 (nuclei), yellow arrow; N, adjacent healthy liver tissue. D. High HDAC8 mRNA expression in HCC is associated with a shorter survival time in HCC patients than that associated with low HDAC8 mRNA expression (Kaplan–Meier survival analysis). E. HDAC8 expression showed a high correlation with AHR mRNA expression. The HDAC8 mRNA expression in HCC tumors with high AHR mRNA expression was significantly higher than that in tumors with low AHR mRNA expression.