Table 1. Baseline characteristics of 289 hepatocellular carcinoma (HCC) patients and 243 non-hepatocellular carcinoma patients.
| Group | Non-HCC (n=243) (%) |
HDAC8 mRNA (Low, n=230)(%) |
HDAC8 mRNA (High; n=59)(%) |
p-value |
|---|---|---|---|---|
| Age (mean(SD)) | 61.6±5.04 | 57.9±2.3 | 59.9±1.4 | 0.6851 |
| Sex Male Female |
154(63.37) 89(36.63) |
164(71.30) 66(28.70) |
48(81.36) 11(18.64) |
0.6017 # |
| GOT (U/L) <40 40≦ <100 100≦ |
214(88.06) 16(6.58) 13(5.36) |
94(40.87) 102(44.35) 34(14.78) |
19(32.20) 26(44.07) 14(23.73) |
0.2670# |
| GPT (U/L) <40 40≦<100 100≦ |
216(88.89) 14(5.76) 13(5.35) |
85(36.96) 106(46.09) 39(16.95) |
21(35.59) 26(44.07) 12(20.34) |
0.8844# |
| Albumin (mg/dL) <4.5 ≧4.5 |
219(90.12) 24(9.88) |
195(84.78) 35(15.22) |
57(96.61) 2(3.39) |
0.0062*# |
| α-Fetoprotein (ng/mL) <20 ≧20 |
218(89.72) 25(10.28) |
130(56.52) 100(43.48) |
34(57.63) 25(42.37) |
0.8909# |
| Bilit 1.5< ≧1.5 |
132(54.32) 111 (45.68) |
189(82.17) 41(17.83) |
50(84.75) 9(15.25) |
0.8223# |
| Lymphovascular invasion No Yes |
243(100)0 | 165(71.74) 65(28.26) |
32(57.14) 27(45.76) |
0.0163*# |
| Size(cm) <2.5 2.5≦ |
82(35.65) 148(64.35) |
8(13.56) 51(86.44) |
0.0020* | |
| Number of tumors 1 1 |
181 (78.70) 49(21.30) |
39(66.10) 20(33.90) |
0.0429* | |
| Modified TNM I II III(IIIA and IIIB) |
153(66.52) 61(26.52) 16(6.96) |
23(38.98) 20(33.90) 16(27.12) |
<0.001* |
#p values were calculated by Fisher exact test
High HDAC8 mRNA expression patients: HDAC8 mRNA expression in tumor part were higher three point six folds (>3.6 folds) than adjacent normal part liver tissue.
Low HDAC8 mRNA expression patients: HDAC8 mRNA expression in tumor part were lesser three point six folds (<3.6 folds) than adjacent normal part liver tissue. (cut point by survival ROC curve)
*p<0.05.
Patients:289HCC patients from two medical centers [Chung Ho Memorial Hospital (255HCC) and Changhua Christian Hospital (34 HCC)] were enrolled into the HDAC8 cohort study from July 2007 to July 2015.