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. 2016 Dec 7;8(5):7572–7585. doi: 10.18632/oncotarget.13810

Figure 5. miR-150 is downregulated during progression of primary CTCL cases.

Figure 5

(A) Photomicrographs of early and tumor phase of mycosis fungoides (MF) samples collected from same patients (MF1 and MF22). Hematoxylin and eosin (H&E) and CD4+ staining are shown. (B) qRT-PCR analysis of miR-150 in tissue samples of normal atopic dermatitis (AD, n = 18), early MF (n = 26), and tumor phase MF (n =14). Y-axis: 2-ΔCt values for miRNA expression. P-values were calculated using Mann-Whitney U test. ***P < 0.001. NS: not significant. (C) Comparison of miR-150 expression between early and tumor MF in same patients (eight cases). #1: miR-150 expression of different clinical courses (MF1, MF6, MF7, and MF22), #2: miR-150 expression of the same patient from different biopsy regions patch/plaque and tumor (MF23, MF24, MF25, and MF28). Student's t-test was used to examine significance. **0.001 ≤ P < 0.01, ***P < 0.001. Bars are means ± standard error of the mean (SEM) of three independent experiments.