Skip to main content
. 2016 Dec 7;8(5):7586–7597. doi: 10.18632/oncotarget.13812

Figure 6. IFN-γ signaling is required for the inhibitory effect of SHP2-deficiency on CAC.

Figure 6

SHP2 and IFN-γR double knockout mice were breed and subjected to AOM-DSS model. (A) The inside of the colon was photographed. (B) The numbers, sizes and load of the tumors were measured. (C) Hematoxylin and eosin (H&E)-stained colonic tissue sections harvested from CAC mice on day 80. Immunochemistry analysis of PCNA expression on colonic tissue sections from CAC mice on day 80. Scale bar, 100 μm. (D) Real-time PCR analysis of Perforin 1, Granzyme B, and FasL in colonic tissues from CAC mice on day 80. Data are representative of three independent experiments (mean ± SEM of 5 mice per group in B, D). *P < 0.05, **P < 0.01.