Table 1. EC50 values after 72 h OTX015 exposure under normoxia and hypoxia in TNBC cell lines.
| Normoxia EC50 (nM) | Emax% | Hypoxia EC50 (nM) | Emax% | PTEN | BRCA1 | TP53 | |
|---|---|---|---|---|---|---|---|
| HCC1937 | 261.5 (38.1–1796) | 70 | 246.9 (58.1–1049) | 54 | Homozygous deletion | Mutated | Mutated |
| MDA-MB-231 | 55.9 (45.3–69.0) | 89 | 49.1 (24.8–96.9) | 82 | Wild type | Wild type | Mutated |
| MDA-MB-468 | 303.8 (91.5–1008) | 80 | 230.0 (38.8–1363) | 72 | Homozygous deletion | Wild type | Wild type |
Results are expressed as the mean concentration that gives half-maximal effect (EC50) with 95% confidence intervals. Emax% indicates the maximum inhibitory response induced by OTX015 on cell proliferation (with respect to control untreated cells). In all cases, n ≥ 4.