Table 2. Efficacy of OTX015, everolimus and paclitaxel in MDA-MB-231 xenograft mice.

Treatment group	Best T/C% (day of treatment)	AGD	LCK
50 mg/kg OTX015	41.3 (23)	10.1	0.41
2 mg/kg RAD001	58.6 (16)	3.6	0.15
OTX015 + RAD001	20.7 (23)	21.6	0.89
0.15 mg/kg paclitaxel	28.9 (23)	17.8	0.64

AGD, absolute growth delay (difference between the average times for each tumor to reach 500 mg in treated and control groups); LCK, log cell kill (log₂ × AGD/tumor doubling time); T/C%, mean tumor mass in treated versus control animals (T/C < 42% is considered active [28, 29] – in bold), RAD001, everolimus.