TABLE 5.
Mutations identified in analyzing the two rpoB hot regions in additional Rifr Brucella mutantsa
| Rifr mutant strain | Missense mutations
|
|
|---|---|---|
| 5′-End region (from cds 118 to 240) | Central region (from cds 473 to 606) | |
| B. melitensis | ||
| BM1R | His-536-Tyr | |
| BM2R | His-536-Tyr | |
| BM3R | His-536-Tyr | |
| B. abortus | ||
| BA3R | His-536-Tyr | |
| BA5R | His-536-Tyr | |
| B. suis | ||
| BS1R | Arg-539-His | |
| BS2R | Val-154-Phe | |
| BS3R | His-536-Tyr | |
a
The rpoB codon numbering is based on the B. melitensis 16M rpoB numbering system (accession no. AE009516). Amino acid changes were identified by comparison with the published B. melitensis 16M sequence. cds, codons.