Table 2. Relation between STAT3 expression level and the clinicopathologic characteristics of ICC patients.
| Variable | STAT3 expression | ||
|---|---|---|---|
| Low (0, 1)n = 83 | High (2, 3) n = 76 | P value | |
| Age (years)* | 50 (29–77) | 52 (32–70) | 0.30# |
| Sex, M:F | 67:16 | 60:16 | 0.78 |
| Total bilirubin (umol/L)* | 13 (6–438) | 13(7–38) | 0.18 |
| ALB (g/L)* | 43 (27–52) | 43(29–52) | 0.89 |
| ALT (u/L)* | 28(6–132) | 34(5–129) | 0.81 |
| AST (u/L)* | 30(12–113) | 33.5(9–111) | 0.31 |
| AFP (μg/L), < 20:≥ 20 | 68:15 | 53:23 | 0.07 |
| CA19-9, ≤ 37:> 37 U/ml | 36:47 | 27:49 | 0.31 |
| CEA, ≤ 5:> 5 ng/ml | 29:54 | 24:52 | 0.65 |
| HBeAg, positive: negative | 15:68 | 18:58 | 0.38 |
| HBsAg, positive: negative | 46:37 | 40:36 | 0.72 |
| HCV, positive: negative | 15:68 | 13:63 | 0.87 |
| Diameter (cm), ≤ 3: 3–5: > 5 | 25:25:33 | 12:20:44 | 0.04 |
| Tumor number, single: multiple | 70:13 | 61:15 | 0.50 |
| Pathological satellite, yes: no | 23:60 | 33:43 | 0.04 |
| Encapsulation, complete: no | 14:69 | 10:66 | 0.92 |
| Vascular invasion, yes: no | 25:58 | 35:41 | 0.04 |
| Cirrhosis, yes: no | 58:25 | 50:26 | 0.58 |
| Differentiation, I:II:III:IV | 17:56:8:2 | 7:43:19:7 | 0.01 |
| Lymph node metastasis, yes: no | 12:71 | 29:47 | 0.00 |
| TNM stage, I–II: III–IV | 64:19 | 42:34 | 0.00 |
*
Median (range). #Mann-Whitney test.
Note: P < 0.05 by Chi-square test or Student t test