Table 4. Univariate Analysis for Overall Survival.

Variables	N	Overall survival		P
		Median±SE	95%CI
Rap1GAP
high	42	50.00±4.32	41.53-58.46
low	136	32.00±0.89	30.37-33.62	<0.001
E-cadherin
high	60	41.00±3.32	34.49-47.50
low	118	32.00±1.80	28.45-35.54	0.091
MMP2
high	102	30.00±1.12	27.80-32.19
low	76	46.00±2.72	40.66-51.33	<0.001
Gender
male	125	34.00±2.97	28.16-39.83
female	53	38.00±3.63	30.86-45.13	0.973
Age
≤60	94	40.00±3.87	32.40-47.59
>60	84	32.00±1.13	29.77-34.22	0.223
TNM
I	21	49.00±3.21	42.69-66.71
II	34	45.00±5.83	33.57-56.42
III	83	34.00±2.27	29.53-38.46
IV	40	29.00±1.57	25.91-32.08	<0.001
Depth of invasion
T1	16	46.00±8.66	29.01-62.98
T2	18	52.00±15.91	20.81-83.18
T3	67	35.00±4.60	25.98-44.01
T4	77	31.00±1.45	28.14-33.86	0.005
Nodal involvement
N0	49	55.00±9.79	35.79-74.20
N1	36	43.00±7.80	27.22-58.78
N2	35	36.00±3.54	29.04-42.95
N3	58	29.00±2.53	24.03-33.96	<0.001
Metastasis
M0	138	40.00±3.91	32.32-47.67
M1	40	29.00±1.57	25.91-32.08	<0.001
Borrmann type
I	22	39.00±7.62	24.06-53.93
II	55	40.00±3.69	32.76-47.23
III	62	34.00±3.50	27.14-40.85
IV	39	30.00±1.77	27.51-34.48	0.502
Differentiation
high	12	40.00±6.06	28.11-51.88
moderate	57	39.00±6.11	26.97-51.02
poor	109	32.00±1.74	28.59-35.41	0.107
Tumor diameter
<3 cm	44	46.00±5.20	35.79-56.20
3 cm-5 cm	54	34.00±1.83	30.40-37.51
>5 cm	80	32.00±0.98	30.06-33.93	0.019