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. 2016 Dec 21;8(5):8095–8104. doi: 10.18632/oncotarget.14098

Figure 2. EBRR4 mutation and protein expression.

Figure 2

Functional domains containing five ERBB4 mutation sites from four CSCNETs A. Predictions for each mutation site indicated that p.P981S is highly conserved across species (mutationassessor.org). Representative IHC staining for ERBB4 B. Tumors, but not adjacent normal tissues, were positive for cytoplasmic ERBB4 expression. Cases 2, 10, and 11 exhibited the strongest expression, cases 13 and 16 showed medium expression, and case 3 showed the lowest expression. Original magnifications are x40 (big image) and x400 (small image). T: tumor tissue; N: adjacent normal tissue