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. 2016 Dec 22;8(5):8131–8142. doi: 10.18632/oncotarget.14101

Figure 5. N-cadherin modulates the activities of the MAPK/Erk, PI3K/Akt and p16/Rb signaling pathways in thyroid cancer.

Figure 5

The lysates from the indicated cells were subjected to western blot analysis. A. The antibodies against phospho-Akt (p-Akt), total Akt (t-Akt), phospho-Erk (p-Erk) and total Erk (t-Erk) were used to determine the effect of N-cadherin kncokdown or overexpression on the activities of the PI3K/Akt and MAPK/Erk pathways. B. The antibodies against p16, phospho-Rb (p-Akt), total Rb (t-Rb) were used to determine the effect of N-cadherin kncokdown or overexpression on the activity of the p16/Rb pathway. GAPDH was used as a loading control.