Table 1. Top 10 GSEA enrichments of differentially expressed genes in response to 96 hour STAT3 knockdown in HCC70.
| Signatures Directly Activated by STAT3 in HCC70 (Down-regulated Upon STAT3 Knockdown) | FDR q-value |
|---|---|
| NABA_MATRISOME | 7.85E-12 |
| NABA_MATRISOME_ASSOCIATED | 1.46E-06 |
| HALLMARK_INFLAMMATORY_RESPONSE | 2.51E-04 |
| NABA_CORE_MATRISOME | 2.51E-04 |
| NABA_ECM_REGULATORS | 6.92E-04 |
| KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | 1.17E-03 |
| REACTOME_IMMUNE_SYSTEM | 1.26E-03 |
| NABA_ECM_GLYCOPROTEINS | 1.26E-03 |
| REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | 2.42E-03 |
| BIOCARTA_IL22BP_PATHWAY | 3.33E-03 |
| Signatures Directly Repressed by STAT3 in HCC70 (Up-regulated Upon STAT3 Knockdown) | FDR q-value |
| NABA_MATRISOME | 2.96E-14 |
| NABA_MATRISOME_ASSOCIATED | 1.30E-10 |
| NABA_SECRETED_FACTORS | 1.10E-07 |
| HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 1.17E-05 |
| REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 3.13E-05 |
| REACTOME_GPCR_LIGAND_BINDING | 4.27E-05 |
| REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | 6.05E-05 |
| HALLMARK_COAGULATION | 9.12E-05 |
| HALLMARK_INFLAMMATORY_RESPONSE | 8.62E-04 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | 8.62E-04 |
Enrichments represent hallmark and canonical pathways in GSEA database. STAT3 responsive genes are enriched for processes involving invasion