Table 2. Top 10 GSEA enrichments of differentially expressed genes in response to 96 hour STAT3 knockdown in MDA-MB-231.
| Signatures Directly Activated by STAT3 in MDA-MB-231 (Down-regulated Upon STAT3 Knockdown) | FDR q-value |
|---|---|
| REACTOME_GPCR_LIGAND_BINDING | 2.59E-04 |
| REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS | 2.77E-04 |
| BIOCARTA_CLASSIC_PATHWAY | 5.36E-04 |
| BIOCARTA_COMP_PATHWAY | 8.54E-04 |
| NABA_MATRISOME | 8.54E-04 |
| KEGG_COMPLEMENT_AND_COAGULATION_CASCADES | 8.59E-04 |
| KEGG_HEMATOPOIETIC_CELL_LINEAGE | 1.94E-03 |
| REACTOME_G_ALPHA_WE_SIGNALLING_EVENTS | 2.03E-03 |
| REACTOME_GPCR_DOWNSTREAM_SIGNALING | 4.23E-03 |
| NABA_ECM_REGULATORS | 4.23E-03 |
| Signatures Directly Repressed by STAT3 in MDA-MB-231 (Up-regulated Upon STAT3 Knockdown) | FDR q-value |
| NABA_SECRETED_FACTORS | 2.03E-06 |
| HALLMARK_HYPOXIA | 9.18E-06 |
| NABA_MATRISOME | 9.18E-06 |
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 3.72E-05 |
| HALLMARK_TNFA_SIGNALING_VIA_NFKB | 1.16E-04 |
| NABA_MATRISOME_ASSOCIATED | 2.63E-04 |
| REACTOME_ACTIVATION_OF_GENES_BY_ATF4 | 1.35E-03 |
| REACTOME_PERK_REGULATED_GENE_EXPRESSION | 1.52E-03 |
| HALLMARK_INFLAMMATORY_RESPONSE | 1.52E-03 |
| HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 2.88E-03 |
Enrichments represent hallmark and canonical pathways in GSEA database. STAT3 responsive genes are enriched for processes involving invasion