Table 3. Summary of meta-analysis of VEGF polymorphisms and RCC risk.
| Polymorphism | No. of studies | No. of cases | No. of controls | Contrast | OR (95% CI) | Statistical method | I2% | P-value |
|---|---|---|---|---|---|---|---|---|
| +936C/T | 6 | 1,445 | 2,337 | TT vs. CC | 1.38(1.11-1.72) | Fixed | 25.3 | 0.004 |
| (rs3025039) | TT vs. CT+CC | 1.28(1.04-1.57) | Fixed | 0.0 | 0.019 | |||
| TT+CT vs. CC | 1.21(1.05-1.39) | Fixed | 38.7 | 0.010 | ||||
| CT vs. CC | 1.17(1.00-1.37) | Fixed | 25.3 | 0.056 | ||||
| T vs. C | 1.20(1.07-1.34) | Fixed | 32.0 | 0.001 | ||||
| −2578C/A | 5 | 1,397 | 2,094 | AA vs. CC | 1.69(1.37-2.07) | Fixed | 0.0 | 0.000 |
| (rs699947) | AA vs. CA+CC | 1.43(1.19-1.73) | Fixed | 0.0 | 0.000 | |||
| AA+CA vs. CC | 1.39(1.21-1.61) | Fixed | 34.8 | 0.000 | ||||
| CA vs. CC | 1.31(1.12-1.52) | Fixed | 47.1 | 0.001 | ||||
| A vs. C | 1.31(1.19-1.45) | Fixed | 0.0 | 0.000 | ||||
| +1612G/A | 3 | 918 | 1,330 | AA vs. GG | 1.25(0.92-1.71) | Fixed | 0.0 | 0.159 |
| (rs10434) | AA vs. GA+GG | 1.20(0.89-1.61) | Fixed | 0.0 | 0.234 | |||
| AA+GA vs. GG | 1.10(0.92-1.31) | Fixed | 0.0 | 0.280 | ||||
| GA vs. GG | 1.08(0.90-1.30) | Fixed | 0.0 | 0.423 | ||||
| A vs. G | 1.10(0.96-1.25) | Fixed | 0.0 | 0.178 | ||||
| −460T/C | 3 | 677 | 1,299 | CC vs. TT | 0.88(0.38-2.01) | Random | 80.6 | 0.758 |
| (rs833061) | CC vs. TC+TT | 0.93(0.47-1.84) | Random | 77.9 | 0.830 | |||
| CC+TC vs. TT | 0.98(0.61-1.58) | Random | 75.5 | 0.928 | ||||
| TC vs. TT | 1.12(0.89-1.41) | Fixed | 31.0 | 0.343 | ||||
| C vs. T | 0.92(0.58-1.46) | Random | 87.9 | 0.720 | ||||
| −634G/C | 3 | 1,038 | 1,716 | CC vs. GG | 1.07(0.84-1.35) | Fixed | 16.4 | 0.581 |
| (rs2010963) | CC vs. GC+GG | 1.00(0.83-1.20) | Fixed | 0.0 | 1.000 | |||
| CC+GC vs. GG | 1.09(0.91-1.30) | Fixed | 0.0 | 0.370 | ||||
| GC vs. GG | 1.08(0.89-1.31) | Fixed | 0.0 | 0.429 | ||||
| C vs. G | 1.03(0.92-1.16) | Fixed | 27.7 | 0.571 | ||||
| −405G/C | 2 | 262 | 477 | CC vs. GG | 1.26(0.45-3.51) | Random | 68.4 | 0.661 |
| (rs2010963) | CC vs. GC+GG | 1.11(0.51-2.41) | Random | 54.5 | 0.796 | |||
| CC+GC vs. GG | 1.18(0.70-2.01) | Random | 52.5 | 0.536 | ||||
| GC vs. GG | 1.11(0.80-1.55) | Fixed | 13.0 | 0.532 | ||||
| C vs. G | 1.14(0.72-1.79) | Random | 67.0 | 0.584 | ||||
| −1154G/A | 2 | 373 | 516 | AA vs. GG | 1.19(0.77-1.84) | Fixed | 19.9 | 0.435 |
| (rs1570360) | AA vs. GA+GG | 1.14(0.76-1.73) | Fixed | 0.0 | 0.528 | |||
| AA+GA vs. GG | 1.00(0.59-1.69) | Random | 58.1 | 0.994 | ||||
| GA vs. GG | 1.08(0.80-1.46) | Fixed | 45.3 | 0.611 | ||||
| A vs. G | 1.01(0.68-1.51) | Random | 57.1 | 0.948 |