Table 3. Association between inflammation-related genetic polymorphisms and the risk of colorectal cancer.
| No. of Controls (%) | Colorectal Cancer | Colon Cancer | Rectal Cancer | ||||
|---|---|---|---|---|---|---|---|
| No. of Cases (%) | Adjusted OR (95% CI)a | No. of Cases (%) | Adjusted OR (95% CI)a | No. of Cases (%) | Adjusted OR (95% CI)a | ||
| IL1B rs4848306 | |||||||
| GG | 393(27.2) | 209(30.1) | 1.0(ref) | 104(29.6) | 1.0(ref) | 102(31.0) | 1.0(ref) |
| GA | 695(49.8) | 339(48.9) | 1.06(0.81–1.27) | 169(48.0) | 0.98(0.74–1.29) | 165(50.2) | 1.09(0.82–1.45) |
| AA | 307(22.0) | 146(21.0) | 0.98(0.74–1.31) | 79(22.4) | 0.90(0.63–1.29) | 62(18.8) | 1.11(0.77–1.60) |
| TNF rs1800629 | |||||||
| GG | 1192(85.1) | 598(86.0) | 1.0(ref) | 302(85.8) | 1.0(ref) | 284(85.8) | 1.0(ref) |
| GA | 203(14.5) | 90(13.0) | 0.88(0.66–1.17) | 46(13.1) | 0.89(0.62–1.28) | 44(13.3) | 0.90(0.62–1.30) |
| AA | 5(0.4) | 7(1.0) | 2.03(0.60–6.89) | 4(1.1) | 2.30(0.58–9.14) | 3(0.9) | 1.82(0.41–8.14) |
| PPARG rs1801282 | |||||||
| CC | 1239(89.1) | 626(89.4) | 1.0(ref) | 323(91.2) | 1.0(ref) | 291(87.4) | 1.0(ref) |
| CG | 143(10.7) | 72(10.3) | 0.84(0.61–1.17) | 30(8.5) | 0.69(0.45–1.07) | 41(12.3) | 1.02(0.69–1.52) |
| GG | 2(0.1) | 2(0.3) | 2.99(0.38–23.33) | 1(0.3) | 2.80(0.24–33.25) | 1(0.3) | 3.30(0.28–39.42) |
| PPARGC1A rs3774921 | |||||||
| TT | 679(48.5) | 316(45.3) | 1.0(ref) | 153(43.5) | 1.0(ref) | 159(47.9) | 1.0(ref) |
| TC | 567(40.5) | 316(45.3) | 1.26(1.02–1.55) | 170(48.3) | 1.40(1.08–1.81) | 139(41.9) | 1.11(0.85–1.45) |
| CC | 154(10.1) | 65(9.3) | 0.91(0.65–1.29) | 29(8.2) | 0.83(0.53–1.31) | 34(10.2) | 0.95(0.61–1.46) |
aAdjusted for education and total calorie intake.