Table 4. Association of DII score with the risk of colorectal cancer, colon cancer, and rectal cancer, stratified by PPARGC1A rs3774921 genetic varianta.
| DII score | Combined effect By SNP and DII | Main effect of DII by the SNP | P for interaction | ||
|---|---|---|---|---|---|
| Low | High | High vs. Low | |||
| Colorectal cancer | |||||
| TT/TC | No.Controls/Cases | 616/246 | 630/386 | ||
| OR (95% CI)b | 1.0 (ref) | 1.61(1.30, 2.00) | 1.63(1.31, 2.02) | 0.009 | |
| CC | No.Controls/Cases | 83/17 | 71/48 | ||
| OR (95% CI)b | 0.46(0.26, 0.82) | 1.90(1.23, 2.94) | 5.15(2.35, 11.29) | ||
| Colon cancer | |||||
| TT/TC | No.Controls/Cases | 616/130 | 630/193 | ||
| OR (95% CI)b | 1.0 (ref) | 1.53(1.17, 2.00) | 1.55(1.19, 2.03) | 0.26 | |
| CC | No.Controls/Cases | 83/11 | 71/18 | ||
| OR (95% CI)b | 0.57(0.29, 1.12) | 1.45(0.81, 2.61) | 3.33(1.24, 8.93) | ||
| Rectal cancer | |||||
| TT/TC | No.Controls/Cases | 616/113 | 630/185 | ||
| OR (95% CI)b | 1.0 (ref) | 1.68(1.27, 2.22) | 1.68(1.27, 2.23) | 0.006 | |
| CC | No.Controls/Cases | 83/6 | 71/28 | ||
| OR (95% CI)b | 0.37(0.15, 0.90) | 2.41(1.43, 4.06) | 8.06(2.67, 24.16) | ||
Abbreviation: DII, dietary inflammatory index; SNP, single nucleotide polymorphism.
aThe DII score was categorized into two groups (high/low) based on the median (1.41) level of the control group.
bAdjusted for education and total calorie intake.