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. 2016 Dec 29;8(5):8574–8589. doi: 10.18632/oncotarget.14351

Figure 8. Targeting ABCC10 reverses FOXM1-elicited 5-FU resistance in vivo.

Figure 8

A. Nude mice were subcutaneously xenografted with FOXM1 overexpression or control CRC cells (5×106) and intraperitoneally injected with 5-FU (5 mg/kg) along with vardenafil (22.4 mg/kg) every three days. Representative images of tumors and tumor volumes are shown. B. Average weight of tumors derived from each group are shown. C. H&E and immunostaining of FOXM1, ABCC10, Ki-67 and TUNEL in tumor sections are shown (scale bar, 25μm). D. Average percentage of Ki-67 positive cells and apoptotic cells in xenografts from each group. Statistical significance was determined by Student's t test. *p<0.05, **p<0.01, ***p<0.001. NS, not significant.