Table 3. Genotypes distribution of SNPs and their associations with the risk of drug addiction.
| SNP ID | Alleles Aa/B | genotype | No. (frequency) | Logistic regression | ||
|---|---|---|---|---|---|---|
| Case (%) | Control (%) | OR(95% CI) | pa | |||
| rs886205 | A/G | GG | 537(77.6) | 512(73.1) | 1 | |
| AA | 9(1.3) | 8(1.1) | 0.696(0.255-1.902) | 0.479 | ||
| AG | 146(21.1) | 180(25.8) | 0.770(0.587-1.008) | 0.057 | ||
| rs441 | C/T | TT | 347(50.1) | 369(52.7) | 1 | |
| CC | 39(5.7) | 67(9.6) | 0.655(0.414-1.036) | 0.070 | ||
| CT | 306(44.2) | 264(37.7) | 1.262(0.994-1.602) | 0.056 | ||
| rs4646778 | A/C | CC | 346(50.1) | 369(52.8) | 1 | |
| AA | 39(5.6) | 67(9.6) | 0.657(0.415-1.040) | 0.073 | ||
| AC | 306(44.3) | 263(37.6) | 1.271(1.001-1.614) | 0.048* | ||
| rs671 | A/G | GG | 452(65.3) | 526(75.1) | 1 | |
| AA | 23(3.3) | 10(1.4) | 2.638(1.180-5.899) | 0.018* | ||
| AG | 217(31.4) | 164(23.5) | 1.646(1.269-2.133) | < 0.001* | ||
| rs11066028 | A/C | CC | 568(82.1) | 573(81.9) | 1 | |
| AA | 7(1.0) | 4(0.6) | 1.409(0.392-5.509) | 0.569 | ||
| AC | 117(16.9) | 123(17.5) | 0.935(0.692-1.263) | 0.662 | ||
a Minor alleles, OR: Odds ratio, CI: Confidence interval;
a
p value were calculated by unconditional logistic regression adjusted by gender and age;
*
p ≤ 0.05; Bonferroni's multiple adjustment was applied, with p<0.00125.