Table 4. Univariate and multivariate survival analyses on PFS in OSCC patients.
| Variables | Reference | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |||
| Age (years) | ||||||||
| <71 | >=71 | 0.882 | 0.365-2.132 | 0.78 | ||||
| Gender | ||||||||
| Female | Male | 0.826 | 0.3168-2.152 | 0.70 | ||||
| Differentiation | ||||||||
| Poorly | Well/moderate | 2.334 | 0.844-6.454 | 0.10 | ||||
| Lymphatic invasion | ||||||||
| Positive | Negative | 2.938 | 1.183-7.297 | 0.02 | 1.533 | 0.408-5.766 | 0.53 | |
| Vascular invasion | ||||||||
| Positive | Negative | 1.914 | 0.779-4.699 | 0.16 | ||||
| Lymph node involvement | ||||||||
| Positive | Negative | 3.260 | 1.336-7.956 | < 0.01 | 1.542 | 0.412-5.776 | 0.52 | |
| T factor | ||||||||
| T3-4 | T1-2 | 0.833 | 0.193-3.606 | 0.81 | ||||
| TNM stage | ||||||||
| III-IV | I-II | 1.770 | 0.717-4.370 | 0.22 | ||||
| Ki-67 | ||||||||
| >=26 | <26 | 2.973 | 1.205-7.333 | 0.02 | 2.180 | 0.800-5.945 | 0.13 | |
| p53 | ||||||||
| Positive | Negative | 1.052 | 0.4266-2.594 | 0.91 | ||||
| CAFs grades | ||||||||
| Grade 3 | Grades 0-2 | 2.532 | 1.033-6.207 | 0.04 | 2.626 | 1.001-6.888 | 0.04 | |
| CD68 | ||||||||
| >=145 | <145 | 4.307 | 1.259-14.742 | 0.02 | 2.382 | 0.633-8.961 | 0.20 | |
| CD163 | ||||||||
| >=80 | <80 | 2.304 | 0.957-5.543 | 0.06 | 1.322 | 0.524-3.338 | 0.55 | |
Abbreviations: PFS, progression-free survival; OSCC, oral squamous cell carcinoma; HR, hazard ratio; CI, confidence interval; CAF, cancer-associated fibroblast.