Table 5. Univariate and multivariate survival analyses on OS in OSCC patients.
| Variables | Reference | Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |||
| Age (years) | ||||||||
| <71 | >=71 | 0.425 | 0.181-0.999 | 0.05 | 0.624 | 0.224-1.735 | 0.37 | |
| Gender | ||||||||
| Female | Male | 0.984 | 0.398-2.428 | 0.97 | ||||
| Differentiation | ||||||||
| Poorly | Well/moderate | 2.771 | 1.070-7.174 | 0.04 | 1.548 | 0.491-4.879 | 0.46 | |
| Lymphatic invasion | ||||||||
| Positive | Negative | 3.745 | 1.522-9.219 | < 0.01 | 1.857 | 0.421-8.197 | 0.41 | |
| Vascular invasion | ||||||||
| Positive | Negative | 4.138 | 1.747-9.802 | < 0.01 | 2.933 | 0.831-10.356 | 0.10 | |
| Lymph node involvement | ||||||||
| Positive | Negative | 2.700 | 1.128-6.461 | 0.03 | 0.820 | 0.174-3.860 | 0.80 | |
| T factor | ||||||||
| T3-4 | T1-2 | 2.963 | 1.060-8.288 | 0.04 | 1.022 | 0.231-4.522 | 0.98 | |
| TNM stage | ||||||||
| III-IV | I-II | 3.188 | 1.338-7.593 | < 0.01 | 1.195 | 0.166-8.597 | 0.86 | |
| Ki-67 | ||||||||
| >=26 | <26 | 3.241 | 1.348-7.788 | < 0.01 | 3.114 | 0.978-9.918 | 0.06 | |
| p53 | ||||||||
| Positive | Negative | 1.563 | 0.646-3.780 | 0.32 | ||||
| CAFs grades | ||||||||
| Grade 3 | Grades 0-2 | 2.809 | 1.210-6.521 | 0.02 | 3.872 | 1.428-10.498 | < 0.01 | |
| CD68 | ||||||||
| >=145 | <145 | 2.332 | 0.859-6.332 | 0.10 | ||||
| CD163 | ||||||||
| >=80 | <80 | 2.335 | 0.993-5.490 | 0.05 | 1.114 | 0.345-3.597 | 0.86 | |
Abbreviations: OS, overall survival; OSCC, oral squamous cell carcinoma; HR, hazard ratio; CI, confidence interval; CAF, cancer-associated fibroblast.