Table 5. Suggested prognostic factors in variable subgroups of SCLC patients.
| Variables | KPS (points) | LDH (U/L) | tumor stage | metastatic sites | Gender | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| >80 | ≤80 | ≤216.5 | >216.5 | LD | ED | <2 | ≥2 | male | female | |
| Surgery | +/− | −/Ø | +/− | −/Ø | −/Ø | −/Ø | +/− | Ø/Ø | −/Ø | +/− |
| Stage | +/+ | +/+ | +/+ | +/+ | Ø/Ø | Ø/Ø | +/+ | Ø/Ø | +/+ | +/+ |
| Chemotherapy cycles | +/− | +/+ | +/+ | −/Ø | −/Ø | +/+ | +/+ | −/Ø | +/+ | +/− |
| Thoracic irradiation | +/+ | +/− | +/+ | +/− | +/+ | +/− | +/+ | −/Ø | +/+ | +/− |
| Metastatic sites | +/+ | −/Ø | +/− | +/− | Ø/Ø | +/+ | Ø/Ø | Ø/Ø | +/+ | +/− |
| Smoking history | +/− | −/Ø | −/Ø | +/+ | +/+ | −/Ø | +/− | −/Ø | −/Ø | +/− |
| NLR | +/− | −/Ø | +/− | −/Ø | −/Ø | +/− | +/− | −/Ø | +/− | −/Ø |
| LMR | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | +/− | −/Ø | −/Ø | +/− | −/Ø |
| Gender | +/− | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | +/− | −/Ø | −/Ø | −/Ø |
| Anemia | +/− | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | +/− | −/Ø | −/Ø | −/Ø |
| RBC | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | +/− |
| LDH | +/+ | +/− | Ø/Ø | Ø/Ø | +/+ | +/+ | +/+ | +/+ | +/+ | +/− |
| ALP | +/− | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | +/− | −/Ø | −/Ø | −/Ø |
| Age | −/Ø | −/Ø | +/− | −/Ø | +/− | −/Ø | +/− | −/Ø | −/Ø | −/Ø |
| PS | Ø/Ø | Ø/Ø | +/+ | +/+ | +/+ | +/+ | +/+ | −/Ø | +/+ | +/+ |
| WBC | −/Ø | −/Ø | −/Ø | +/+ | −/Ø | −/Ø | −/Ø | +/+ | −/Ø | −/Ø |
| Family history | −/Ø | −/Ø | −/Ø | −/Ø | +/+ | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø |
| Lymphocytes | −/Ø | −/Ø | −/Ø | +/− | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø |
| Neutrophils | −/Ø | −/Ø | −/Ø | +/+ | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø | −/Ø |
+/+=significant on both univariate and multivariate analysis; +/−=significant on univariate analysis, not significant on multivariate analysis; −/Ø=not significant on univariate analysis and not assessed on multivariate analysis; Ø/Ø= not studied, the parameters used were the same with Table 2 and factors with no statistical significance in variable subgroups were not shown.