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. 2017 Jan 2;8(5):8679–8692. doi: 10.18632/oncotarget.14412

Figure 4. DPPIV inhibitor induces cell cycle arrest, induces apoptosis; DPPIV knockdown and the chemotherapy sensitivity test; DPPIV overexpression increases tumorigenicity.

Figure 4

A. DPPIV depletion induces cell cycle arrest at G0/G1, while DPPIV overexpression increases cells enter into S and G2 phase. B. DPPIV depletion induces apoptosis (B) in AN3CA cells, as determined by flow cytometry. C. DPPIV knockdown inhibited cell proliferation, similar to the effects of cisplatin. **P < 0.001, there were no synergistic effects associated with DPPIV knockdown and concurrent cisplatin treatment after 48, 72 and 96h. (P >0.05). The 95% confidence interval is (-0.887, -0.00129), (-0.960, -0.684), (-0.1560, -0.07248) respectively. D. DPPIV overexpression and knockdown compare with they control group at 8 weeks after injection. a, overexpression control; b, DDPIV overexpression; c, shRNA control; d, LV-shRNA. The graph is representative of three experiments.