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. 2017 Jan 2;8(5):8752–8764. doi: 10.18632/oncotarget.14436

Figure 3. Inhibition of let-7a alleviated the downregulation of β1-AR and improved cardiac function in a rat model of CIHF.

Figure 3

A. let-7a in CIHF treated with len-pre-let-7a, len-AMO-let-7a, or len-NC; B and C. β1-AR protein and mRNA expression in CIHF treated with len-let-7a, len-AMO-let-7a, or len-NC; D and E. Cardiac function of rats by echocardiography; F. Heart rate (HR) of rats in models of CIHF. Date are expressed as mean ± SD, n = 5-10 in each group; *P < 0.05 vs Sham,#P < 0.05 vs MI,&P < 0.05 vs MI + Len-pre-let-7a.