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. 2017 Jan 2;8(5):8791–8800. doi: 10.18632/oncotarget.14456

Figure 3. Inhibition of ERK1/2 and p38 attenuated CS-induced EMT in SV-HUC-1 cells.

Figure 3

A. U0126 suppressed the activation of p-ERK1/2, p-c-Fos, p-c-Jun and alterations of EMT markers induced by CS exposure. B. SB203580 diminished the activation of p-p38, p-c-Fos, p-c-Jun and alterations of EMT markers induced by CS exposure. C. SP600125 could not decreased the activation of p-c-Fos and alterations of EMT markers induced by CS exposure. D. SV-HUC-1 cells became collective and full after treated with U0126 and SB203580. SP600125 can not attenuated morphological change triggered by CS. E. Enhanced invasion capacity of SV-HUC-1 cells triggered by CSE was reversed by U0126 and SB203580. F. Immunofluorescent staining confirmed U0126 and SB203580 not only increased the expression of E-cadherin in membrane but also decreased the expression of Vimentin in cytoplasm. * p< 0.05 and ** p < 0.01, represented CSE group compared with control group. # p<0.05, represented inhibitor of MAPK pathways group compared with respective CSE group.