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. 2017 Jan 2;8(5):8791–8800. doi: 10.18632/oncotarget.14456

Figure 5. Inhibitors of ERK1/2 and p38 pathways diminished CS-induced urocystic EMT in the bladder of mice.

Figure 5

A. U0126 attenuated CS-induced alterations in the expression of p-c-Fos, p-c-Jun, E-cadherin and Vimentin in proteins level. B. SB203580 attenuated CS-induced alterations in the expression of p-c-fos, p-c-jun as well as E-cadherin and Vimentin in proteins level. C. SP600125 could not reverse the expression change of p-c-Fos together with E-cadherin and Vimentin in proteins level. D. and E. U0126 and SB203580 diminished CS-induced urocystic EMT in the bladder of mice in mRNA level. SP600125 could not reversed the EMT change triggered by CS. Data are expressed as mean ±SD. * p< 0.05 and ** p < 0.01, compared with FA control; # p <0.05, represented CS group compared with respective inhibitor of MAPK pathways.