Table 2. Interaction genes and nutrients.
| Biological Process | Gene | Polymorphism | Genotype | Biomarker | Nutritional Factor | Dose genotype dependent |
|---|---|---|---|---|---|---|
| INFLAMMATION | MTHFR | 677 C/T | C/C | Homocysteine | Folic Acid | 200 (μg/day) |
| C/T | 400 (μg/day) | |||||
| T/T | 800 (μg/day) | |||||
| MTHFR | 1298 A/C | AA | Homocysteine | Folic Acid | 200 (μg/day) | |
| AC | 400 (μg/day) | |||||
| CC | 800 (μg/day) | |||||
| IL-6 | −174 G/C | G/G | C-Reactive ProteinLipoxygenaseFibrinogen | Ù 3 | 1,5 (g/day) | |
| G/C | 1,5-3 (g/day) | |||||
| C/C | 1,5-3 (g/day) | |||||
| TNF- α | −308 G/A | G/G | Ù 3 | 1,5 (g/day) | ||
| G/A | 1,5-3 (g/day) | |||||
| A/A | 1,5-3 (g/day) | |||||
| STRESS OXIDATIVE | SOD2 | −28 C/T | CC | LDL ossidateNO2/NO3ANPCORAC | Ù 3 | 1,5 (g/day) |
| CT | 1,5-3 (g/day) | |||||
| TT | 1,5-3 (g/day) | |||||
| CYP1A2 | −163 A/C | AA | Ù 3 | 1,5 (g/day) | ||
| AC | 1,5-3 (g/day) | |||||
| CC | 1,5-3 (g/day) | |||||
| GSTM1 | ID | II | Ù 3 | 1,5 (g/day) | ||
| ID | 1,5-3 (g/day) | |||||
| DD | 1,5-3 (g/day) | |||||
| LIPIDS METABOLISM | APOA1 | −75 G/A | GG | LDL oxidized | PUFA | < 4% |
| GA | 4 – 8% | |||||
| AA | > 8% | |||||
|
Legend Table 2: APOA1: Apolipoprotein A1 CYP1A2:Cytochrome P450 1A2 GSTM1: Glutathione S-transferase Mu 1 IL-6: interleukin-6 MTHFR: methylenetetrahydrofolate reductase SOD2: Superoxide dismutase 2 TNF-α: tumor necrosis factor alpha | ||||||
Personalized diet therapy intervention and nutrients dose change according to genetic polymorphisms.