Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Neurooncol. 2016 Nov 17;131(3):449–458. doi: 10.1007/s11060-016-2319-2

Figure 3. Analysis of correlation of circulating sTNF-R1 in patients with recurrent GBM and overall survival independent of age and steroid use.

Figure 3

(Panel a) The levels of sTNF-R1 in the vascular circulation of patients with recurrent GBM (n=46) were analyzed for an association with age. The correlation was assessed using Linear Regression analysis after adjusting for cohort (p value=0.04). (Panels b-d), The levels of sTNF-R1 in the vascular circulation of patients undergoing surgery for recurrent GBM (n=46; CCF1 and CCF2 cohorts) were determined by ELISA analysis and plotted against their overall survival in months. The correlation with overall survival was assessed using the Cox Proportional Hazards Model adjusting for cohort (p value=0.03) (Panel b), adjusting for cohort and age (p value=0.02) (Panel c), and adjusting for cohort, age and steroid use (Panel d). The data are plotted as Kaplan-Meier survival curves for elevated sTNF-R1 (red line) versus not elevated sTNF-R1 (blue line) (Panels b-d).