Figure 1. OA-NO2 suppresses cutaneous ear swelling in a model of ACD.
(a) Balb/c mice were sensitized and CHS was elicited with DNFB ± contralateral SC injections of OA-NO2, OA (negative control), or VC (vehicle control), according to diagram. The CHS response was analyzed at time points indicated following elicitation. (b) Bars represent the increase in ear thickness mean ± SEM of 4-5 mice per group. One representative of four individual experiments. *indicates a significant difference compared to the DNFB treated group at each time point, p < 0.05. (c) Ear swelling over an extended time course. Each point represents the mean ± SEM of 4-5 mice per group. (d) 72 h following elicitation ears were excised and cross-sections were stained with H&E. Scale bar = 50 μm.