Table 2.

Regression coefficients from Cox models and hazard ratios for incident diabetes for an interquartile range increase^* in variables of the longitudinal change in hormone levels among 1407 women, Study of Women’s Health Across the Nation

	Model 1		Model 2		Model 3
	β (se)	HR (95% CI)	β (se)	HR (95% CI)	β (se)	HR (95% CI)
Oestradiol
Intercept (pre-menopausal)	−0.0316 (0.0144)	0.52 (0.29, 0.93)‡	−0.0218 (0.0160)	0.64 (0.34, 1.22)	−0.0309 (0.0171)	0.53 (0.27, 1.06)†
Slope for early transition	0.0377 (0.0659)	1.07 (0.84, 1.37)	0.0178 (0.0699)	1.03 (0.80, 1.34)	0.0539 (0.0764)	1.11 (0.83, 1.47)
Slope for late transition	−0.0321 (0.0184)	0.61 (0.35, 1.06)	−0.0196 (0.0213)	0.74 (0.39, 1.41)	−0.0311 (0.0223)	0.62 (0.32, 1.21)
FSH
Intercept (pre-menopausal)	0.0054 (0.0139)	1.20 (0.48, 3.00)	0.0117 (0.0141)	1.48 (0.58, 3.77)	0.0121 (0.0141)	1.51 (0.59, 3.81)
Slope for early transition	−0.2360 (0.0910)	0.25 (0.09, 0.71)¶	−0.1787 (0.0904)	0.35 (0.12, 0.99)‡	−0.1953 (0.0947)	0.31 (0.10, 0.94)‡
Slope for late transition	0.0261 (0.0276)	1.33 (0.74, 2.39)	0.0134 (0.0265)	1.16 (0.66, 2.03)	0.0257 (0.0288)	1.32 (0.72, 2.44)

FSH, follicle-stimulating hormone; HR, hazard ratio.

Model 1: adjusted for baseline age; Model 2: Model 1 + baseline BMI; Model 3: Model 2 + race/ethnicity, education and smoking status.

^*Interquartile ranges for the oestradiol model: 75.2 pmol/L for the intercept; 7.0 pmol/L/year for the early transition slope; 56.5 pmol/L/year for the late transition slope. IQRs for the FSH model: 33.7 IU/L for the intercept; 5.9 IU/L/year for the early transition slope; 10.8 IU/L/year for the late transition slope.

^†P<0.1,

^‡P<0.05,

^¶P<0.01.