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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Sep 15;67:141–152. doi: 10.1016/j.semcdb.2016.09.004

Figure 7. Long distance mechanical interactions accelerate cancer cell invasion.

Figure 7

Transformed mammary acini orient collagen fibrils (orange) perpendicular to the invasive boundary, which serves as a track for metastatic cells (left). If two transformed mammary acini are within a critical distance, they will interact mechanically to produce a long, collagen fibril superhighway. Metastatic cells are observed to move at a faster rate via the superhighway than they do along a self-generated track that is not linked to a neighbor track.