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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Chem Neuroanat. 2016 Sep 15;83-84:99–106. doi: 10.1016/j.jchemneu.2016.09.006

Table 3.

Comparison of IC50 values of Decynium22 and GBR12935 for hPMAT-, rPmat- and mPmat-mediated MPP+ transport between humans, rats and mice.

Inhibitors IC50 (µM)
hPMAT rPmat mPmat
Decynium22 0.124 ± 0.080 0.309 ± 0.062 0.591 ± 0.054†
GBR12935 30.0 ± 7.9 25.2 ± 1.4 62.8 ± 4.5†

IC50 values were obtained from the data presented in Fig. 6. N.D., not determined.

†

P < 0.05, significantly different from IC50 value of each compound for hPMAT-mediated MPP+ transport. Data are shown as means ± SEM (n = 3).