Table 1.

Summary of aging impacts on ECM molecules in the left ventricle

ECM component		Changes	Type	Species	Reference
Collagen	Type I	↓	mRNA	C57BL/6C57BL/6	(Toba et al. 2016)
	Type III	↓	mRNA	Wistar rat; C57BL/6	(Mamuya et al. 1992; Toba et al. 2016)
		↓	Protein	C57BL6/J	(Padmanabhan Iyer et al. 2016)
	Type IV	↓	mRNA	C57BL/6	(Toba et al. 2016)
	Type V	↓	mRNA	C57BL/6	(Toba et al. 2016)
	Type XV	↓	Protein	C57BL6/J	(Padmanabhan Iyer et al. 2016)
Procollagen	Type I	↓	mRNA	Fischer 344 rat	(Thomas et al. 2000)
	Type III	↓	mRNA	Fischer 344 rat	(Thomas et al. 2000)
Glycosaminoglycan	Hyaluronan	↓	Protein	Sprague-Dawley rat	(Hellstrom et al. 2006)
Glycoproteins	Fibronectin	↑	Protein	Balb-c mice	(Burgess et al. 2001)
		↓	mRNA	Wistar rat; C57BL/6	(Mamuya et al. 1992; Toba et al. 2016)
	Laminin-α2	↑	mRNA	C57BL/6	(Toba et al. 2016)
	Laminin-γ1	↓	mRNA	C57BL/6	(Toba et al. 2016)
	Periostin	↑	mRNA	C57BL6/J	(Ma et al. 2012)
		↑	mRNA	C57BL6/J	(Chiao et al. 2012)
Integrin	α1	↑	Protein	Balb-c mice	(Burgess et al. 2001)
	α3	↑	mRNA	C57BL/6	(Toba et al. 2016)
	α5	↑	Protein	Balb-c mice	(Burgess et al. 2001)
	αE	↑	mRNA	C57BL/6	(Toba et al. 2016)
	β1	↓	Protein	Balb-c mice	(Burgess et al. 2001)
		↓	mRNA	Wistar rat; C57BL/6	(Mamuya et al. 1992; Toba et al. 2016)
Matricellular	SPARC	↑	Protein	C57Bl6/SV129 mice	(Bradshaw et al. 2010)
proteins	Thrombospondin-2	↑	mRNA	C57BL/6J	(Ma et al. 2012)
		↑	Protein	C57Bl6/129SvJ/EMS + Ter mice	(Swinnen et al. 2009)
	Osteopontin	↓	mRNA	C57BL/6	(Chiao et al. 2012)
		↓	mRNA	Sprague-Dawley rat	(Graf et al. 1997)

↑ increased, ↓ decreased. ECM extracellular matrix, SPARC secreted protein acidic and rich in cysteine