. 2017 Feb 20;22(2):173–189. doi: 10.1007/s12192-017-0776-y

Table 2.

Summary of HSPA8 contacts with CHIP, J, and various chemicals

CHIP^a	MKT-077^b	DOPS^c	J-domain^d		PET-16^e		Myricytin^f		115-7c^g		Telmisartan^h
T641	R76	K569	D208	E213	L392	L394	K55	K56	T173	T177	R56	N57
I642	A148	K573	D211	D214	D393	D395	R56	N57	A174	A178	M89	W90
E643	Y149	K583	G212	G215	V394	V396	Q57	Q58	A176	A180	F91	F92
E644	F150	K589	T215	I216	T395	T397	A58	V59	L177	I181	R261	R264
V645	T222	K601	F216	F217	P396	P398	V59	A60	G180	G184
D646	A223		E217	E218	L397	L399	L66	V67	L181	L185
	G224		D326	D323	L399	L401	F67	F68	D182	D186
	D225				I418	I420	G74	G75	K183	K187
	T226				Q442	E444	I88	H89	N187	E192
	H227				I478	I480	M89	W90	R188	R193
	L228				A480	A482	F91	F92	T189	N194
					D481	N483	K92	M93	A191	L196
					G482	G484	V103	V105	V192	I197
					A503	N505	K106	K108	S203	S208
					S504	D506	A111	S113	I204	I209
							N222	A223	I205	L210
							G223	G224	D211	D214
							E230	E231	G212	G215
							I237	V238	T215	I216
							M259	V260	F216	F217
							Q260	R261	E217	E218
							L262	L263
							E267	E268

^aFrom NMR intensity perturbations of human wt-HSPA8

^bFrom NMR Chemical Shift Perturbation (CSP) in human HSPA8 (1–386)

^cFrom NMR CSP in human HSPA8 (387–604) and mutagenesis of full-length HSPA8

^dFrom Paramagnetic Relaxation Enhancement NMR for E. coli DnaK(1–608). Left column: DnaK count, right column: human HSPA8 count

^e3A proximities between compound and E. coli DnaK in the crystal structure (4R5G). Left DnaK count, right HSPA8 count

^fFrom NMR CSP in E. coli DnaK (1–388) Left DnaK count, Right: HSPA8 count

^gFrom NMR CSP in E. coli DnaK (1–388) Left DnaK count, Right: HSPA8 count

^hFrom NMR CSP in E. coli DnaK (1–388) Left DnaK count, Right: HSPA8 count